An evidence-based approach to acute respiratory distress syndrome.
Identifieur interne : 000543 ( Main/Exploration ); précédent : 000542; suivant : 000544An evidence-based approach to acute respiratory distress syndrome.
Auteurs : M O Meade [Canada] ; M S HerridgeSource :
- Respiratory care [ 0020-1324 ] ; 2001.
Descripteurs français
- KwdFr :
- Administration par inhalation (MeSH), Adulte (MeSH), Bronchodilatateurs (administration et posologie), Bronchodilatateurs (usage thérapeutique), Congrès comme sujet (MeSH), Décubitus ventral (MeSH), Essais contrôlés randomisés comme sujet (MeSH), Hormones corticosurrénaliennes (usage thérapeutique), Humains (MeSH), Monoxyde d'azote (administration et posologie), Monoxyde d'azote (usage thérapeutique), Médecine factuelle (MeSH), Nouveau-né (MeSH), Syndrome de détresse respiratoire de l'adulte (thérapie), Syndrome de détresse respiratoire du nouveau-né (thérapie), Ventilation artificielle (MeSH).
- MESH :
- administration et posologie : Bronchodilatateurs, Monoxyde d'azote.
- thérapie : Syndrome de détresse respiratoire de l'adulte, Syndrome de détresse respiratoire du nouveau-né.
- usage thérapeutique : Bronchodilatateurs, Hormones corticosurrénaliennes, Monoxyde d'azote.
- Administration par inhalation, Adulte, Congrès comme sujet, Décubitus ventral, Essais contrôlés randomisés comme sujet, Humains, Médecine factuelle, Nouveau-né, Ventilation artificielle.
English descriptors
- KwdEn :
- Administration, Inhalation (MeSH), Adrenal Cortex Hormones (therapeutic use), Adult (MeSH), Bronchodilator Agents (administration & dosage), Bronchodilator Agents (therapeutic use), Congresses as Topic (MeSH), Evidence-Based Medicine (MeSH), Humans (MeSH), Infant, Newborn (MeSH), Nitric Oxide (administration & dosage), Nitric Oxide (therapeutic use), Prone Position (MeSH), Randomized Controlled Trials as Topic (MeSH), Respiration, Artificial (MeSH), Respiratory Distress Syndrome, Adult (therapy), Respiratory Distress Syndrome, Newborn (therapy).
- MESH :
- chemical , administration & dosage : Bronchodilator Agents, Nitric Oxide.
- chemical , therapeutic use : Adrenal Cortex Hormones, Bronchodilator Agents, Nitric Oxide.
- therapy : Respiratory Distress Syndrome, Adult, Respiratory Distress Syndrome, Newborn.
- Administration, Inhalation, Adult, Congresses as Topic, Evidence-Based Medicine, Humans, Infant, Newborn, Prone Position, Randomized Controlled Trials as Topic, Respiration, Artificial.
Abstract
We provide an evidence-based approach to managing patients with acute lung injury and acute respiratory distress syndrome (ARDS). We searched MEDLINE and the Cumulative Index to Nursing and Allied Health for randomized trials evaluating lung-protective ventilation strategies, inhaled nitric oxide, prone positioning, and late-phase corticosteroids for managing these patients, and for additional literature related to long-term follow-up of ARDS survivors. The results of our review suggest that pressure- and volume-limited ventilation, according to the ARDS Network protocol, can reduce mortality for patients with acute lung injury, and so may an "open lung" approach to mechanical ventilation. Those 2 strategies are currently being compared in 2 multicenter randomized trials. Although both inhaled nitric oxide therapy and prone positioning can produce dramatic acute improvements in oxygenation for some patients, there is no evidence that these interventions can benefit patients with respect to patient-important outcomes. Therefore it is unreasonable to be dogmatic about the role of inhaled nitric oxide and prone positioning in ARDS. The role of corticosteroids in the late phase of ARDS is unclear and remains a very important unanswered question. With respect to long-term follow-up, we found that pulmonary dysfunction is probably not a major source of morbidity for ARDS survivors, whereas neuropsychological dysfunction is prominent. Ongoing research may suggest interventions to improve the outcome of ARDS and of critical illness in general.
PubMed: 11728297
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and the Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada. meadema@hhsc.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine and the Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario</wicri:regionArea>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Inhalation (MeSH)</term>
<term>Adrenal Cortex Hormones (therapeutic use)</term>
<term>Adult (MeSH)</term>
<term>Bronchodilator Agents (administration & dosage)</term>
<term>Bronchodilator Agents (therapeutic use)</term>
<term>Congresses as Topic (MeSH)</term>
<term>Evidence-Based Medicine (MeSH)</term>
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<term>Infant, Newborn (MeSH)</term>
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<term>Nitric Oxide (therapeutic use)</term>
<term>Prone Position (MeSH)</term>
<term>Randomized Controlled Trials as Topic (MeSH)</term>
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<term>Adulte (MeSH)</term>
<term>Bronchodilatateurs (administration et posologie)</term>
<term>Bronchodilatateurs (usage thérapeutique)</term>
<term>Congrès comme sujet (MeSH)</term>
<term>Décubitus ventral (MeSH)</term>
<term>Essais contrôlés randomisés comme sujet (MeSH)</term>
<term>Hormones corticosurrénaliennes (usage thérapeutique)</term>
<term>Humains (MeSH)</term>
<term>Monoxyde d'azote (administration et posologie)</term>
<term>Monoxyde d'azote (usage thérapeutique)</term>
<term>Médecine factuelle (MeSH)</term>
<term>Nouveau-né (MeSH)</term>
<term>Syndrome de détresse respiratoire de l'adulte (thérapie)</term>
<term>Syndrome de détresse respiratoire du nouveau-né (thérapie)</term>
<term>Ventilation artificielle (MeSH)</term>
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<term>Nitric Oxide</term>
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<term>Bronchodilator Agents</term>
<term>Nitric Oxide</term>
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<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Bronchodilatateurs</term>
<term>Monoxyde d'azote</term>
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<term>Respiratory Distress Syndrome, Newborn</term>
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<term>Syndrome de détresse respiratoire du nouveau-né</term>
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<term>Congresses as Topic</term>
<term>Evidence-Based Medicine</term>
<term>Humans</term>
<term>Infant, Newborn</term>
<term>Prone Position</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Respiration, Artificial</term>
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<term>Adulte</term>
<term>Congrès comme sujet</term>
<term>Décubitus ventral</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Humains</term>
<term>Médecine factuelle</term>
<term>Nouveau-né</term>
<term>Ventilation artificielle</term>
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<front><div type="abstract" xml:lang="en">We provide an evidence-based approach to managing patients with acute lung injury and acute respiratory distress syndrome (ARDS). We searched MEDLINE and the Cumulative Index to Nursing and Allied Health for randomized trials evaluating lung-protective ventilation strategies, inhaled nitric oxide, prone positioning, and late-phase corticosteroids for managing these patients, and for additional literature related to long-term follow-up of ARDS survivors. The results of our review suggest that pressure- and volume-limited ventilation, according to the ARDS Network protocol, can reduce mortality for patients with acute lung injury, and so may an "open lung" approach to mechanical ventilation. Those 2 strategies are currently being compared in 2 multicenter randomized trials. Although both inhaled nitric oxide therapy and prone positioning can produce dramatic acute improvements in oxygenation for some patients, there is no evidence that these interventions can benefit patients with respect to patient-important outcomes. Therefore it is unreasonable to be dogmatic about the role of inhaled nitric oxide and prone positioning in ARDS. The role of corticosteroids in the late phase of ARDS is unclear and remains a very important unanswered question. With respect to long-term follow-up, we found that pulmonary dysfunction is probably not a major source of morbidity for ARDS survivors, whereas neuropsychological dysfunction is prominent. Ongoing research may suggest interventions to improve the outcome of ARDS and of critical illness in general.</div>
</front>
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<Abstract><AbstractText>We provide an evidence-based approach to managing patients with acute lung injury and acute respiratory distress syndrome (ARDS). We searched MEDLINE and the Cumulative Index to Nursing and Allied Health for randomized trials evaluating lung-protective ventilation strategies, inhaled nitric oxide, prone positioning, and late-phase corticosteroids for managing these patients, and for additional literature related to long-term follow-up of ARDS survivors. The results of our review suggest that pressure- and volume-limited ventilation, according to the ARDS Network protocol, can reduce mortality for patients with acute lung injury, and so may an "open lung" approach to mechanical ventilation. Those 2 strategies are currently being compared in 2 multicenter randomized trials. Although both inhaled nitric oxide therapy and prone positioning can produce dramatic acute improvements in oxygenation for some patients, there is no evidence that these interventions can benefit patients with respect to patient-important outcomes. Therefore it is unreasonable to be dogmatic about the role of inhaled nitric oxide and prone positioning in ARDS. The role of corticosteroids in the late phase of ARDS is unclear and remains a very important unanswered question. With respect to long-term follow-up, we found that pulmonary dysfunction is probably not a major source of morbidity for ARDS survivors, whereas neuropsychological dysfunction is prominent. Ongoing research may suggest interventions to improve the outcome of ARDS and of critical illness in general.</AbstractText>
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